In this project area, we will focus on the circuit construction and transitions responsible for adaptive brain functions. Combining advanced neuroscience techniques for measuring and manipulating neural circuit activity with cutting-edge techniques for single-cell gene expression analysis will provide detailed information about cell type–specific adaptive circuits (Adaptive Circuit Census: ACC). Based on the adaptive circuit census, we will experimentally validate the responsible circuits and theoretically establish their operating principles.

 

 

 

To further promote the ACC project area, we have established a seamless, interdisciplinary cooperative framework to exchange creative and innovative ideas as well as cutting-edge experimental and analytical techniques. The project subareas are divided into A01, "Census of adaptive circuit construction," and B01, "Census of adaptive circuit transition," based on the differences of the timescale. In addition, the project subarea C01, "Technology and theory for adaptive circuit census," interacts with A01 and B01 to facilitate targeting of adaptive circuits (Research organization chart).
The A01 project subarea is organized by the Horie, Shimogori, and Fujiyama teams; the B01 project subarea is organized by the Isomura, Sasaki, and Kobayashi teams; and the C01 project subarea is organized by the Go and Shimazaki teams. In addition, publicly invited research teams will participate in each project subarea in the first and second terms of the project area. Together with the A01, B01, and C01 teams, publicly invited research teams will provide interdisciplinary approaches to study various adaptive brain functions in different species and stimulate this novel research area.

Research Organization

ACC (project area)
Project Leader: Yoshikazu Isomura

A01
"Cell type census for adaptive circuit construction"

Construction mechanism of basic design for adaptive neuronal circuits

Co-investigator

Yutaka Satou

Associate Professor
Department of Zoology, Graduate School of Science, Kyoto University

Co-investigator

Haruka Ozaki

Associate Professor
Faculty of Medicine, University of Tsukuba

Cell type census for circuit development

Team leader

Tomomi Shimogori

Team Leader
RIKEN Center for Brain Science

Co-investigator

Ai Nakashima

Associate Professor
Graduate School of Pharmaceutical Sciences, University of Tokyo

Mechanism for building diversity of neural projections responsible for behavioral selection

Team leader

Fumino Fujiyama

Professor
Faculty of Medicine and Graduate School of Medicine, Hokkaido University

Co-investigator

Nobuhiko Ohno

Professor
Department of Anatomy, Division of Histology and Cell Biology, Jichi Medical University

B01
" Cell type census for adaptive circuit transition"

Adaptive circuit dynamics for operant learning of optimal behavior

Team leader

Yoshikazu Isomura

Professor
Graduate School of Medical and Dental Sciences, Institute of Science Tokyo

Co-investigator

Nobuya Sato

Professor
School of Humanities, Kwansei Gakuin University

Co-investigator

Fuyuki Karube

Assistant Professor
Graduate School of Medicine, Hokkaido University

Neuronal circuit dynamics and gene expression profiles related to memory states

Team leader

Takuya Sasaki

Professor
Graduate School of Pharmaceutical Sciences, Tohoku University

Co-investigator

Akihiro Funamizu

Lecturer
Institute for Quantitative Biosciences, The University of Tokyo

Gene and cell function dynamics underlying behavioral adaptation in response to environments

Team leader

Kazuto Kobayashi

Professor
Institutes of Biomedical Sciences
Fukushima Medical University School of Medicine

Co-investigator

Natsuki Matsushita

Associate Professor
Division of Laboratory Animal Research, Aichi Medical University School of Medicine

Co-investigator

Susumu Setogawa

Lecturer
Department of Physiology, Osaka Metropolitan University Graduate School of Medicine

C01/02
"Technology and theory for adaptive circuit census"

C01 Development of comprehensive cell type census technology for adaptive neuronal circuits

Team leader

Yasuhiro Go

Professor
The Graduate School of Information Science, University of Hyogo

Co-investigator

Itoshi Nikaido

Team Leader
Laboratory for Bioinformatics Research
RIKEN Center for Biosystems Dynamics Research

C02 Theoretical approaches to adaptive neuronal circuits identified by the cell type census

Team leader

Hideaki Shimazaki

Associate Professor
Graduate School of Informatics, Kyoto University

Co-investigator

Takuma Tanaka

Associate Professor
Graduate School of Data Science, Shiga University

Publicly invited research teams (FY2024-2025)

A01

Identification of hub networks for fear memory by combining optical and machine-learning-based approaches with comprehensive molecular profiling methods.

Identification of hub networks for fear memory by combining optical and machine-learning-based approaches with comprehensive molecular profiling methods.

Masakazu Agetsuma

Senior Researcher
Institute for Quantum Life Science, National Institutes for Quantum Science and Technology (QST)

Adaptive circuit diversity causing natural variation in temperature acclimation

Adaptive circuit diversity causing natural variation in temperature acclimation

Atsushi Kuhara

Professor
Konan University, Faculty of Science and Engineering / Institute for Integrative Neurobiology

Exploring the molecular basis of sexual dimorphism and evolutionary processes in the brain during visual partner selection

Exploring the molecular basis of sexual dimorphism and evolutionary processes in the brain during visual partner selection

Hideaki Takeuchi

Professor
Graduate School of Life Sciences, Tohoku University

Dissecting the adaptive circuit construction mechanisms by co-profiling of neuronal differentiation state and transcriptome

Dissecting the adaptive circuit construction mechanisms by co-profiling of neuronal differentiation state and transcriptome

Naoki Nakagawa

Assistant professor
National Institute of Genetics, Laboratory of Mammalian Neural Circuits

Investigating the neural circuits involved in environmental adaptation in sessile cnidarian coral using a combination of in vivo and in vitro approaches

Investigating the neural circuits involved in environmental adaptation in sessile cnidarian coral using a combination of in vivo and in vitro approaches

Koki Nishitsuji

Associate Professor
Department of Marine Science and Technology, Fukui Prefectural University

Neural mechanism underlying sex differences in sleep

Neural mechanism underlying sex differences in sleep

Hiromasa Funato

 Visiting Professor
International Institute for Integrative Sleep Medicine, University of Tsukuba

Construction and Transition of Cell Assembly by Neuronal Individuality Census

Construction and Transition of Cell Assembly by Neuronal Individuality Census

Takeshi Yagi

Professor
Graduate School of Frontier Biosciences
The University of Osaka

B01

Understanding Roles of Molecular Signatures in Transition of Fear Memory Circuits in the Hippocampus by Fear Memory Engram Census

Understanding Roles of Molecular Signatures in Transition of Fear Memory Circuits in the Hippocampus by Fear Memory Engram Census

Satoshi Kida

Professor
Graduate School of Agriculture and Life Sciences, The University of Tokyo

Social circuit transition mechanisms in autism

Social circuit transition mechanisms in autism

Toru Takumi

 Professor
Kobe University School of Medicine

Novel Adaptive Circuit Derived from Neural Reorganization and Impairment Recovery Models via Synthetic Synapse Connectors

Novel Adaptive Circuit Derived from Neural Reorganization and Impairment Recovery Models via Synthetic Synapse Connectors

Kosei Takeuchi

Professor
Aichi Medical University, School of Medicine

Exploring the diversity of activity-dependent translatome dynamics

Exploring the diversity of activity-dependent translatome dynamics

Hiromu Tanimoto

Professor
Graduate School of Life Sciences, Tohoku University

Census analyses of neural circuits that adaptively generate distinct behaviors

Census analyses of neural circuits that adaptively generate distinct behaviors

Akinao Nose

Professor
Graduate School of Frontier Sciences, The University of Tokyo

Local circuit census by retro-barcode

Local circuit census by retro-barcode

Kosuke Hamaguchi

Associate Professor
Kyoto University Graduate School of Medicine, Department of Biological Sciences

Transcriptome/synaptome analysis of single-cell adaptive circuit remodeling in the brain in vivo

Transcriptome/synaptome analysis of single-cell adaptive circuit remodeling in the brain in vivo

Takayasu Mikuni

Professor
Brain Research Institute, Niigata University

C01

Elucidation of brain transformation dynamics via transcription factor activity census

Elucidation of brain transformation dynamics via transcription factor activity census

Kentaro Abe

Professor
Graduate School of Life Sciences, Tohoku University

Comprehensive epigenomic analysis by a novel method for isolating specific types of neurons using FISH

Comprehensive epigenomic analysis by a novel method for isolating specific types of neurons using FISH

Yusuke Kishi

Associate Professor
The University of Tokyo, Institute for Quantitative Biosciences

Development of single-cell spatial epigenomics technology for adaptive circuit census

Development of single-cell spatial epigenomics technology for adaptive circuit census

Tetsuro Komatsu

Lecturer
Gunma University, Institute for Molecular and Cellular Regulation

Development of highly efficient trans-synaptic AAV capsid mutants

Development of highly efficient trans-synaptic AAV capsid mutants

Ayumu Konno

Lecturer
Gunma University, Gunma University Graduate School of Medicine

Spatio-Temporal Proteomics Decipher Molecular Mechanisms of Adaptive Neural Circuits

Spatio-Temporal Proteomics Decipher Molecular Mechanisms of Adaptive Neural Circuits

Tetsuya Takano

JST・PRESTO
Associate Professor, Division of Molecular Systems for Brain Function, Kyushu University Institute for Advanced Study, Medical Institute of Bioregulation

Chromatin Census Based on Neural Circuit Imaging

Chromatin Census Based on Neural Circuit Imaging

Mizuki Honda

Assistant Professor
Hiroshima University, Graduate School of Integrated Sciences for Life

C02

Distilling Adaptive Dynamics from Neuronal Populations Composed of Diverse Dynamical Information Processing Units

Distilling Adaptive Dynamics from Neuronal Populations Composed of Diverse Dynamical Information Processing Units

Yasuhiro Tsubo

Professor
College of Information Science and Engineering Ritsumeikan University

Publicly invited research teams (FY2022-2023)

A01

Identification of hub networks for fear memory by combining optical and machine-learning-based approaches with comprehensive molecular profiling methods.

Identification of hub networks for fear memory by combining optical and machine-learning-based approaches with comprehensive molecular profiling methods.

Masakazu Agetsuma

Senior Researcher
Institute for Quantum Life Science

Mechanisms of neural circuit formation in a mouse model of autism

Mechanisms of neural circuit formation in a mouse model of autism

Atsuki Kawamura

Assistant professor
Graduate School of Medical Sciences, Kanazawa University

Circuit selection and function building census in animal temperature acclimatization

Circuit selection and function building census in animal temperature acclimatization

Atsushi Kuhara

Professor
Graduate school of Natural Science & Institute for Integrative Neurobiology, Konan University

Unraveling the Molecular/Neural Underpinnings of Sexual Dimorphism in Mating Strategies Using 3D Modality Analysis Techniques

Unraveling the Molecular/Neural Underpinnings of Sexual Dimorphism in Mating Strategies Using 3D Modality Analysis Techniques

Hideaki Takeuchi

Professor
Graduate School of Life Sciences, Tohoku University

Dissecting the mechanisms underlying adaptive circuit construction by profiling the inter-neuronal heterogeneity of differentiation

Dissecting the mechanisms underlying adaptive circuit construction by profiling the inter-neuronal heterogeneity of differentiation

Naoki Nakagawa

Assistant professor
National Institute of Genetics

Understanding of the adaptive neural circuit of sedentary cnidarian coral living in various environment

Understanding of the adaptive neural circuit of sedentary cnidarian coral living in various environment

Koki Nishitsuji

Associate Professor
Department of Marine Science and Technology, Fukui Prefectural University

Complex circuit formation and cell assembly formation and transition by neuronal individuality census

Complex circuit formation and cell assembly formation and transition by neuronal individuality census

Takeshi Yagi

Professor
Graduate School of Frontier Biosciences
Osaka University

B01

Neural Circuit Mechanisms of Decision Making Based on Active Inference

Neural Circuit Mechanisms of Decision Making Based on Active Inference

Hitoshi Okamoto

Team Leader
RIKEN Center for Brain Science

Neural census of adaptive circuit shift for proactive and trial-and-error strategy

Neural census of adaptive circuit shift for proactive and trial-and-error strategy

Kei Oyama

Senior Researcher
Department of Functional Brain Imaging, National Institutes for Quantum Science and Technology

Understanding Molecular Basis of Circuit Transition from Reconsolidation to Extinction by Fear Memory Engram Census

Understanding Molecular Basis of Circuit Transition from Reconsolidation to Extinction by Fear Memory Engram Census

Satoshi Kida

Professor
Graduate School of Agriculture and Life Sciences, The University of Tokyo

Dynamics of synaptic memory circuit

Dynamics of synaptic memory circuit

Akihiro Goto

Program-Specific Associate professor
Kyoto University Graduate School of Medicine, Department of Pharmacology

Mapping of adaptive neuronal circuits for developmental song learning in zebra finches

Mapping of adaptive neuronal circuits for developmental song learning in zebra finches

Yoko Yazaki-Sugiyama

Associate Professor
Neuronal Mechanism for Critical Period Unit, OIST Graduate University

Mechanism of circuit adaptation through translatome dynamics

Mechanism of circuit adaptation through translatome dynamics

Hiromu Tanimoto

Professor
Graduate School of Life Sciences, Tohoku University

Modification mechanism of neural circuit dynamics responsible for memory transition by neuropeptides

Modification mechanism of neural circuit dynamics responsible for memory transition by neuropeptides

Ayako Tonoki

Associate Professor
Graduate School of Pharmaceutical Sciences, Chiba University

Census analyses of neural circuits that adaptively generate distinct behaviors

Census analyses of neural circuits that adaptively generate distinct behaviors

Akinao Nose

Professor
Graduate School of Frontier Sciences, The University of Tokyo

Census of the functional neuron activity in the fronto-striatal circuit

Census of the functional neuron activity in the fronto-striatal circuit

Satoshi Nonomura

Lecturer
Shiga University of Medical Science

Local Circuit Analysis with Retrograde Barcodes

Local Circuit Analysis with Retrograde Barcodes

Kosuke Hamaguchi

Associate Professor
Graduate School of Medicine, Kyoto University

Spatiotemporal mechanisms for the adaptive circuit rearrangement in single neurons in vivo

Spatiotemporal mechanisms for the adaptive circuit rearrangement in single neurons in vivo

Takayasu Mikuni

Professor
Brain Research Institute, Niigata University

C01

Transcription factor activity census for elucidating mechanism behind brain plasticity

Transcription factor activity census for elucidating mechanism behind brain plasticity

Kentaro Abe

Professor
Graduate School of Life Sciences, Tohoku University

Simultaneous voltage and calcium imaging and mRNA extraction from single neurons in-vivo

Simultaneous voltage and calcium imaging and mRNA extraction from single neurons in-vivo

Christopher Roome

Staff Scientist
Okinawa Institute of Science and Technology Graduate University (OIST)

C02

Extracting Adaptive Neural Networks through Spike Statistical Techniques for Heterogeneous Neural Populations

Extracting Adaptive Neural Networks through Spike Statistical Techniques for Heterogeneous Neural Populations

Yasuhiro Tsubo

Professor
College of Information Science and Engineering Ritsumeikan University

A seamless neuroscience research group, such as one that combines single-cell gene analysis techniques and circuit manipulation, has not been effectively created in Japan. Therefore, we established the research support committee (histological analysis, physiological analysis, behavioral analysis, gene manipulation, and theoretical/statistical analysis support teams) and transcriptomic analysis support committee (collaboration coordination and RNA-seq analysis unit) within the executive committee of the Administrative organization (Admin organization chart).
In addition to systematic technological support, we provide a variety of support to stimulate scientific activities for ACC researchers, including academic exchanges, international moves, fostering of young researchers, and contributions to society. Overall, we aim to understand the true "Adaptive Circuit Census" by obtaining valuable research findings using innovative technologies, thus providing a seamless collaboration platform for the next generation of young researchers.

 

Admin Organization

 

Executive committeeYoshikazu Isomura, Takeo Horie, Tomomi Shimogori, Fumino Fujiyama,
Takuya Sasaki, Kazuto Kobayashi, Yasuhiro Go, Hideaki Shimazaki
Research
support committee
Kobayashi (chair)Histological analysis support unitFujiyama
Physiological analysis support unitSasaki, Funamizu, Isomura
Behavioral analysis support unitSato (n)
Gene manipulation support unitKobayashi, Matsushita
Theoretical/statistical analysis support unitShimazaki, Ozaki, Tanaka
Transcriptomic analysis
support committee
Go (chair)Collaboration coordination unitGo, Horie
RNA-seq analysis unitGo, Horie, Ozaki, Nikaido
Young researcher support committee
Global activity stimulation committee
Conference planning committee
Outreach committee
External evaluation committee
ACC office
Sasaki
Shimogori
Horie
Fujiyama
Masahiko Watanabe (Hokkaido Univ.), Masanobu Kano (Tokyo Univ.), Noriyuki Sato (OIST), Nenad Sestan (Yale Univ.)
Isomura

* Horie had participated until August 2024.